en Review Paper Review Paper <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span lang="EN-US" new="" roman="" style="font-family:" times="">As a major global cause of liver disease, non-alcoholic fatty liver disease&nbsp;(NAFLD) is characterized by excessive hepatocellular accumulation of lipids in the liver, elevated levels of hepatic enzymes, and fibrotic evidence. The primary therapies for NAFLD are changing lifestyle or managing comorbid-associated diseases.&nbsp;Lately, nanotechnology has revolutionized the art of nanostructure synthesis for disease imaging, diagnosis, and treatment. Loading drugs into nanocarriers has been established as a promising strategy to extend their circulating time, particularly in treating&nbsp;NAFLD. In addition, considering a master modulator of adipogenesis and lysosomal biogenesis and function, designing novel nanostructures for biomedical applications requires using biodegradable materials. Various nanostructures, including inorganic nanoparticles (NPs), organic-based NPs, metallic nanocarriers, biodegradable polymeric nanocarriers, polymer-hybrid nanocarriers, and lipid-based nanocarriers have been designed for NAFLD treatment, which significantly affected serum glucose/lipid levels and liver function indices. NPs modified with polymers, bimetallic NPs, and superparamagnetic NPs have been used to design sensitive nanosensors to measure NAFLD-related biomarkers. However, certain limitations are associated with their use as diagnostic agents. The&nbsp;purpose&nbsp;of this review article is&nbsp;to&nbsp;shed&nbsp;light on the recent advancements in the field of nanomedicine for the early diagnosis, treatment, and prognosis of this progressive liver disease<span style="background:white">.</span></span></span></span></span><br> &nbsp; Biomaterials,Nanomaterials,Drug delivery,Nanotechnology,Non-alcoholic fatty liver disease (NAFLD). 1 28 http://ijmse.iust.ac.ir/browse.php?a_code=A-10-4036-3&slc_lang=en&sid=1 Saman Sargazi sgz.biomed@gmail.com 1800319475328460017019 1800319475328460017019 Yes Zahedan University of Medical Sciences Mahtab Ghasemi Toudeshkchouei mahtabghasemi2543@gmail.com 1800319475328460017020 1800319475328460017020 No University of Tehran Abbas Rahdar a.rahdar@uoz.ac.ir 1800319475328460017021 1800319475328460017021 No University of Zabol Aisha Rauf maisha.rauf001@gmail.com 1800319475328460017022 1800319475328460017022 No Grand Asian University, Sialkot Pakistan Quaid I Azam University Soheil Amani soheilamani28@gmail.com 1800319475328460017023 1800319475328460017023 No Institute for Advanced Studies in Basic Sciences (IASBS) Razieh Behzadmehr razi.behzadmehr@gmail.com 1800319475328460017024 1800319475328460017024 No Department of Radiology, Zabol university of medical sciences Ana M. Diez-Pascual am.diez@uah.es 1800319475328460017025 1800319475328460017025 No Universidad de Alcalá Francesco Baino francesco.baino@polito.it 1800319475328460017026 1800319475328460017026 No Politecnico di Torino Muhammad Bilal 1800319475328460017027 1800319475328460017027 No School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China