en Review Paper Review Paper Recently, using calcium phosphates and at the top of them, hydroxyapatite (HA) has been considered in medical and dental applications as an artificial biomaterial due to their chemical and structural similarity to the bodychr('39')s skeletal tissues such as bone and tooth. Because of reinforcement of hydroxyapatitechr('39')s mechanical and biological properties by substitution of OH- groups by F- ions to produce fluorapaptite (FA) has been proven, in this article synthesis methods, properties and medical applications of fluorapatite and its pros and cons in comparison with hydroxyapatite have been reviewed. Fluorapatite,Hydroxyapatite,Tissue engineering,Biomaterial,Biomedical application,Synthesis and characterization,Calcium phosphates 1 20 http://ijmse.iust.ac.ir/browse.php?a_code=A-10-4058-1&slc_lang=en&sid=1 Seyedali Seyedmajidi s.majidi.dvm@gmail.com 1800319475328460014831 1800319475328460014831 Yes Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Maryam Seyedmajidi ms_majidi79@yahoo.com 1800319475328460014832 1800319475328460014832 No Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.